PLHOST analysis
provided following conserved residues for the various mitochondrial encoded
proteins.
3rd and 4th columns are coordinates for the
conserved fragments.
SNPScore maps the SNP to protein sequence and scores for
SNPs present in these conserved blocks
|
Peptide |
start |
end |
mut |
Disease |
|
|
ND1 |
LLLIVPIL |
7 |
14 |
|
|
|
|
|
|
|
|
|
|
ND2 |
LLTLSILS |
154 |
161 |
|
|
|
|
ALTTLLLP |
331 |
338 |
331 |
Alzeimer disease |
|
|
|
|
|
|
|
|
ND3 |
EIALLLPL |
68 |
75 |
|
|
|
|
LQTTNLPL |
79 |
86 |
82 |
Sporadic Ataxia Patients |
|
|
|
|
|
|
|
|
ND4 |
LLIALIYT |
160 |
167 |
164 |
Sporadic Ataxia Patients |
|
|
LLKLGGYG |
235 |
242 |
236 |
Sporadic Ataxia Patients |
|
|
IAYSSISHM |
286 |
294 |
|
|
|
|
|
|
|
|
|
|
ND4L |
No |
|
|
|
|
|
|
|
|
|
|
|
|
ND5 |
FIGWEGVG |
141 |
148 |
|
|
|
|
GLLLAAAG |
215 |
222 |
|
|
|
|
|
|
|
|
|
|
ND6 |
No |
|
|
|
|
|
|
|
|
|
|
|
|
ATP6 |
ALAVRLTANITAGHLLMHLIGS |
155 |
176 |
161 |
Ataxia |
|
|
IIFTILIL |
191 |
198 |
|
|
|
|
|
|
|
|
|
|
ATP8 |
No |
|
|
|
|
|
|
|
|
|
|
|
|
MTCO1 |
No |
|
|
|
|
|
|
|
|
|
|
|
|
MTCO2 |
No |
|
|
|
|
|
|
|
|
|
|
|
|
MTCO3 |
ATGFHGLHV |
200 |
208 |
|
|
|
|
AAAWYWHFVD |
237 |
246 |
|
|
|
|
|
|
|
|
|
|
MCYTB |
FMGYVLPWGQMSFWGATVIT |
128 |
147 |
134 |
Sporadic Ataxia Patients |
|
|
ADLLILTW |
330 |
337 |
|
|