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Acute Lymphoblastic Leukemia

Acute Lymphoblastic Leukemia (ALL) is one of the most common heterogeneous diseases observed in paediatric age group and it differs in both, immunophenotypic and molecular characters. ALL is a complex blood disorder characterized by various underlying genetic abnormalities that block B or T cell differentiation and support abnormal cell proliferation. The incidence of ALL is about 60% of all acute leukemias in children. MicroRNAs (miRNAs), a class of small non-coding RNAs, regulate gene expression at transcriptional and post-transcriptional level and are found to be deregulated in various cancers including leukemias. Increasing evidences suggest the involvement of microRNAs in the development of different types of leukemias by the deregulation of various signaling pathways such as Jak-Stat, Notch, NF-kB etc. To provide an overall idea regarding the complex interaction among miRNAs, their plausible targets and the associated pathways, extensive mining of miRNAs implicated in ALL was carried out from different databases. The data has been compiled in order to provide collective information in a single platform, LeukmiR. This database with an easy user-interface, query based enquiry could provide the required information in a snapshot to the users in a retrievable form. Herein, we also report 51 novel miRNAs and their targets that are experimentally validated in human Acute Lymphoblastic Leukemia samples.